Fig. 1

NK cell immunotherapy strategies. Different strategies for NK cell immunotherapy. First, treatments with cytokines to promote NK cell proliferation and activation; Second, treatment with antibodies or inhibitory receptors for NK cell and ADCC activation or facilitate NK cell cytotoxic activity; third, adoptive NK cell immunotherapy (autologous or allogenic NK cell transfer); fourth, treatments with cell-free derivations (Exos) of NK cells for overcome direct cells using limitations