Fig. 4
From: Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art
The roles of NK-Exos in immunostimulatory (modulation), immunosuppression, and cytotoxic activities. NK-Exos exert their effects through different mechanisms depending on bioactive molecules including therapeutic drugs, miRNAs (MiRs), and cytotoxic proteins which carried. Paclitaxel (PTX) loaded-Exos, kill tumor cells; MiR-3607 loaded-Exos, prevent invasion of cancer cells; MiR-186 loaded-Exos, suppressing cell proliferation and inducing; cytotoxic proteins loaded-Exos, kill cancer cells by caspase-dependent and -independent apoptotic pathways