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Fig. 3 | Cancer Cell International

Fig. 3

From: SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53

Fig. 3

Alteration of SQLE and the association between SQLE expression and immune cell infiltration in BCa. (A) Alteration frequency of SQLE in BCa and pan-cancer. (B) The mutation sites, types of mutation, and alteration frequency of SQLE somatic mutation in BCa. (C) The correlation between tumor mutation burden and expression of SQLE. (D) The stromal, immune, and ESTIMATE scores were different between low-expression SQLE and high-expression SQLE. (E) SQLE expression was positively associated with CD4 + Th2 T cells, plasma cells, CD8 + T cells, and macrophage infiltration in BCa and negatively correlated with CD4 + T cells, myeloid-derived suppressor cells, and NK cells. (F) Gene expression after ICB treatment and in responders and non-responders in different tumor models. (*p < 0.05, **p < 0.01, ***p < 0.001)

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Cancer Cell International

ISSN: 1475-2867

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