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Fig. 6 | Cancer Cell International

Fig. 6

From: SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53

Fig. 6

Knockdown of SQLE affects the P53 signaling pathway and PTEN/AKT/GSK3β signaling pathway. (A) The top 147 genes associated with SQLE were constructed with a PPI network (23 genes were not found in the STRING platform); (B) KEGG enrichment analysis of genes in PPI network; (C) GO enrichment analysis of genes in PPI network; (D) Protein expression levels of P53, PTEN, AKT, P-AKT, GSK3β, and P-GSK3β in T24 and 5637 cells; (E–G) Representative images of P53, PTEN, and P-AKT immunostaining. Data represent the mean ± SD of three independent experiments. (*p < 0.05, **p < 0.01, ***p < 0.001 versus the vector group, ns, not significant)

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Cancer Cell International

ISSN: 1475-2867

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