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Fig. 9 | Cancer Cell International

Fig. 9

From: SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53

Fig. 9

SQLE increases tumor cell proliferation, migration, and invasion by regulating the PTEN/AKT/GSK3β signaling pathway through P53 in vivo. (A–B) Representative image of T24 xenograft tumors under different treatments; (C) Tumor weight in each group; (D) Tumor volume in each group; (E) Expression levels of P53, PTEN, P-AKT, P-GSK3β, cyclin D1, and Bcl2 of xenograft tumors in each group as determined by the western blot assay; (F) Expression of P-AKT, PTEN, P53, Cyclin D1 and Bcl2 in xenograft tumors was analyzed by immunohistochemical staining and TUNEL staining assays. The nucleus is blue and the brownish-yellow stain is positive; the darker the color, the higher the level of gene expression. Data represent the mean ± SD of three independent experiments. (*p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant)

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Cancer Cell International

ISSN: 1475-2867

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