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Fig. 6 | Cancer Cell International

Fig. 6

From: Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest

Fig. 6

HYAL2 knockdown induces glioma cell cycle arrest and apoptosis. (A) GSEA indicated that HYAL2 expression was related to cell cycle regulation in glioma. (B) The cell cycle of U251 cells was detected by flow cytometry after treatment with HYAL2 siRNA for 48 h. (C) The relative expression of CCNB1 and CCND1 proteins in U251 and LN229 cell lines was detected by Western blotting after treatment with HYAL2 siRNA for 48 h. (D) GSEA indicated that HYAL2 expression was related to apoptosis regulation in glioma. (E) Apoptosis in U251 cells was detected by flow cytometry after treatment with HYAL2 siRNA for 48 h. (F) The relative expression of Bcl-2 and BAX proteins in U251 and LN229 cell lines was detected by Western blotting after treatment with HYAL2 siRNA for 48 h. Bars represent the mean ± SD; *P < 0.05, **P < 0.01, and ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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