Table 4 Combination index for palbociclib combined with PI3K inhibitors against three different AML cell lines
From: Combination strategies to overcome drug resistance in FLT+ acute myeloid leukaemia
Cell Line | Inhibitor (+palbociclib) | Combination index | |||
|---|---|---|---|---|---|
Fa 0.25 | Fa 0.5 | Fa 0.75 | Fa 0.9 | ||
MOLM-13 | Copanlisib | 0.03 | 0.20 | 1.16 | 7.21 |
MOLM-13 | Alpelisib | 0.64 | 0.86 | 1.18 | 1.63 |
MOLM-13 | Duvelisib | 0.06 | 0.27 | 1.24 | 5.78 |
MOLM-13 | Idelalisib | 0.73 | 0.87 | 1.05 | 1.28 |
MOLM-13 | Quizartinib | 0.06 | 0.54 | 5.02 | 46 |
MOLM-14 | Copanlisib | 0.32 | 0.44 | 0.61 | 0.84 |
MOLM-14 | Alpelisib | 0.39 | 0.30 | 0.23 | 0.17 |
MOLM-14 | Duvelisib | 0.25 | 0.19 | 0.25 | 0.34 |
MOLM-14 | Idelalisib | 0.71 | 0.27 | 0.18 | 0.15 |
MOLM-14 | Quizartinib | 0.05 | 0.02 | 0.01 | 0.006 |
MV4-11 | Copanlisib | 0.10 | 0.32 | 1.07 | 3.96 |
MV4-11 | Alpelisib | 0.84 | 0.71 | 0.62 | 0.56 |
MV4-11 | Duvelisib | 0.24 | 0.95 | 3.79 | 15 |
MV4-11 | Idelalisib | 0.11 | 0.34 | 1.43 | 6.56 |
MV4-11 | Quizartinib | 0.05 | 0.28 | 1.79 | 11.27 |