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Fig. 8 | Cancer Cell International

Fig. 8

From: Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments

Fig. 8

The GSEA analyses the mRNA sequencing between GBM8401 with scrambled siRNA and GBM8401 with siINTS9. (A) PCA plot demonstrated distinct transcriptome features between groups. (B-F) GSEA analysis showed significant upregulation of E2F_TARGETS, MYC_TARGETS_V1/V2, and UV_RESPONSE_UP in the higher INTS9 group. (G) Additionally, ATAC sequencing revealed INTS9 expression linked to chromatin accessibility of E2F1 and E2F3

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Cancer Cell International

ISSN: 1475-2867

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