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Fig. 6 | Cancer Cell International

Fig. 6

From: Semaphorin 3 C enhances putative cancer stemness and accelerates peritoneal dissemination in pancreatic cancer

Fig. 6

Preclinical trial using the peritoneal dissemination mouse model. (A) Experimental design of the peritoneal dissemination model (untreated group / GnP group; GEM- (120 mg/kg) and nab-paclitaxel (120 mg/kg))-injected PKCY cells transduced with control and SEMA3C shRNA into the peritoneal cavity. (B) Image depicting the distribution of peritoneal dissemination nodes localized majorly in the parietal peritoneum and mesentery. (C) Schematic overview of the PCI score to evaluate peritoneal dissemination in mice. (D) PCI score for the GnP group in box-plot histograms. Each score represents the mean ± SEM. (E) Waterfall plot indicating changes in the PCI score compared with baseline (mean PCI score of each no treated group)

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Cancer Cell International

ISSN: 1475-2867

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