Semaphorin 3 C enhances putative cancer stemness and accelerates peritoneal dissemination in pancreatic cancer

Table 1 Relationship between SEMA3C expression and clinicopathological features of PDAC patients

Parameters	SEMA3C expression		P value
Parameters	High (n = 69)	Low (n = 53)	P value
Gender (Male/Female)	31/38	29/24	0.28
Age (y.o. median: range)	70 (38–82)	71 (50–86)	0.86
CA19-9 (median: range)	213.2 (0-15600)	105 (0.1–1787)	0.02
Tumor volume (mm³ median: range)	5233 (67-24647)	2355 (157-32153)	0.0003
UICC Stage (IA,IB,IIA,IIB/III,IV) ^a	45/24	38/15	0.45
pT1, 2/pT3, 4 ^a	2/67	8/45	0.01
pN0/pN1, 2 ^a	20/49	16/37	0.89
ly (+/−)	68/1	44/7	0.006
v (+/−)	60/9	40/12	0.15
ne (+/−)	67/2	43/9	0.006
PL (+/−)	18/46	8/43	0.11

chi-square test, Mann–Whitney–Wilcoxon test
p; pathological findings, T; primary tumor, N; regional lymph nodes, ly; lymphatic invasion, v; venous invasion, ne; neural invasion, PL; extra pancreatic nerve plexus invasion
^a The Union for International Cancer Control 8th edition

ISSN: 1475-2867