Table 4 Variations of HPV18 E6 gene from patients with different grades of cervical lesions
No. | Grade of cervical lesion | Type of variant | 104 | 149 | 153 | 232 | 287 | 317 | 377 | 382 | 485 | 549 | 554 | Accession number |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Reference | T | T | C | A | G | T | A | T | T | C | C | AY262282 |
1 | Normal | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572475 |
2 | Normal | A1 | – | – | – | – | – | G* | – | – | – | – | – | OP572476 |
3 | Normal | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572477 |
4 | Normal | A1 | – | – | – | – | – | – | – | G* | – | – | – | OP572478 |
5 | Normal | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572479 |
6 | Normal | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572480 |
7 | Normal | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572481 |
8 | Normal | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572482 |
9 | Normal | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572483 |
10 | Normal | A4 | C | – | – | – | C* | – | – | – | C | A | – | OP572484 |
11 | Normal | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572485 |
12 | Normal | A5 | C | C | – | – | – | – | G | – | C | A | – | OP572486 |
13 | LSIL/CIN1 | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572487 |
14 | LSIL/CIN1 | A1 | – | C* | – | – | – | – | – | – | – | – | – | OP572488 |
15 | LSIL/CIN1 | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572489 |
16 | LSIL/CIN1 | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572490 |
17 | LSIL/CIN1 | A1 | – | – | – | – | – | – | – | – | – | – | T* | OP572491 |
18 | LSIL/CIN1 | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572492 |
19 | LSIL/CIN1 | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572493 |
20 | LSIL/CIN1 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572494 |
21 | LSIL/CIN1 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572495 |
22 | LSIL/CIN1 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572496 |
23 | LSIL/CIN1 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572497 |
24 | LSIL/CIN1 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572498 |
25 | HSIL/CIN2-3 | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572499 |
26 | HSIL/CIN2-3 | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572500 |
27 | HSIL/CIN2-3 | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572501 |
28 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572502 |
29 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572503 |
30 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572504 |
31 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572505 |
32 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572506 |
33 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572507 |
34 | HSIL/CIN2-3 | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572508 |
35 | HSIL/CIN2-3 | A5 | C | C | T* | – | – | – | G | – | C | A | – | OP572509 |
36 | HSIL/CIN2-3 | A5 | C | C | – | – | – | – | G | – | –* | –* | – | OP572510 |
37 | SCC | A1 | – | – | – | – | – | – | – | – | – | – | – | OP572511 |
38 | SCC | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572512 |
39 | SCC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572513 |
40 | SCC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572514 |
41 | SCC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572515 |
42 | SCC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572516 |
43 | SCC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572517 |
44 | ADC | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572518 |
45 | ADC | A3 | C | – | – | G | – | – | – | – | C | A | – | OP572519 |
46 | ADC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572520 |
47 | ADC | A4 | C | – | – | – | – | – | – | – | C | A | – | OP572521 |
48 | ADC | A5 | C | C | – | – | – | – | G | – | C | A | – | OP572522 |
Amino acid substitution | - | - | – | E33G | – | F71L | – | L93R | – | – | – |  | ||