Fig. 2

SYNPO2 involve in the process of autophagy. The upper part shows that SYNPO2 interacts with 14-3-3β, BPV-E5, and BAG3, increasing their binding with receptors on the mitochondria and accelerating the accumulation of this complex on the membrane of the mitochondria, leading to the generation of mitophagy. The lower part depicts that SYNPO2 expression facilitates the recruitment of CASA-associated proteins to drive cargo degradation for lysosome-dependent degradation after HSC70 binds with the KFERQ motif. The process is inhibited by blocking the interaction between SYNPO2 and BAG3 or by a lack of SYNPO2, corresponding to overactivation of STK38 and JG98 treatment, respectively