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Fig. 1 | Cancer Cell International

Fig. 1

From: Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway

Fig. 1

Glycolysis-related hub genes were screened by TCGA database and MSigDB database. (A) In TCGA-KIRC (|log (FC)|>1, P < 0.05), compared with normal tissues, 4687 up-regulated genes and 4207 down-regulated genes were selected. (B) The intersection of 4687 up-regulated genes and 753 glycolysis-related genes was used to select 124 glycolysis-related differentially expressed genes (DEGs). (C) By analyzing the association between 124 glycolysis-related DEGs, a PPI network was established, and 86 hub genes were ultimately screened. (D-G) Incorporating 86 hub genes and 7 clinicopathological information into univariate cox regression analysis, 38 hub genes were selected. (H-I) Incorporating 19 hub genes into the receiver operating characteristic (ROC) curve, and selecting 12 hub genes with area under curve (AUC) > 0.9. TCGA, The Cancer Genome Atlas; MSigDB, Molecular Signatures Database; KIRC, Kidney Renal clear Cell Carcinoma; DEGs, differentially expressed genes; PPI, Protein-Protein interaction; ROC, receiver operating characteristic; AUC, Area under curve

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Cancer Cell International

ISSN: 1475-2867

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