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Fig. 2 | Cancer Cell International

Fig. 2

From: Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway

Fig. 2

Correlation between glycolysis-related hub gene TCIRG1 and immune response. (A) GSEA enrichment analysis shows that TCIRG1 is significantly enriched on the Interferon gamma response. (B) TIMER database shows the correlation between TCIRG1 expression level (log2 TPM) and CD4 + T Cell (Infiltration Level). (C) Correlation between the expression of TCIRG1 and the immune score of ccRCC (Stromal Score, Tumor Purity, Immuno Score, and Estimate Score) based on Pearson correlation analysis. (D) K-M survival curve, relationship between OS of ccRCC and Stromal Score, Tumor Purity, Immune Score, and Estimate Score. (all p values were defined as *p < 0.05, **p < 0.01 and ***p < 0.001, log rank test). TCIRG1, T-cell immune regulator 1; GSEA, Gene Set Enrichment Analysis; TIMER, Tumor Immune Estimation Resource; K-M, Kaplan-Meier; ccRCC, clear cell renal cell carcinoma; OS, Overall survival

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Cancer Cell International

ISSN: 1475-2867

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