Skip to main content
Fig. 4 | Cancer Cell International

Fig. 4

From: Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway

Fig. 4

Correlation between expression of TCIRG1 and immune characteristics of ccRCC. (A) LinkedOmics database analysis shows that in the KEGG pathway, TCIRG1 was enriched in immune related pathway antigen processing and presentation. (B) Biological processes in gene ontology (GO) analysis indicates that TCIRG1 is enriched in immune related biological processes, including response to interferon-gamma, adaptive immune response, positive regulation T cell activation. (C) TIMER 2.0 Gene_DE module analysis shows the correlation between TCIRG1 gene expression (log2 TPM) and indicated immune cell infiltration level in the KIRC dataset based on the XCELL algorithm. The partial Spearman’s correlation is used to perform this association analysis. (D) TIMER 2.0 Gene_Corr module analysis shows that TCIRG1 expression was correlated with the indicated immune cell marker genes (Th1: IFNG, CXR3; CD8 + T cell: CD8A, CD8B; NK cell: KIR2DL4, KIR3DL2; M1 macrophage: IRF5, IL12A). (E) Single-cell expression matrix and corresponding statistical chart from TISCH2 database illustrating the expressive abundance of TCIRG1 in different clusters of immune cells based on KIRC_GSE111360 data set. (F-G) TISIDB analysis shows a correlation between TCIRG1 expression and Immunoinhibitors in the KIRC dataset. KEGG, Kyoto Encyclopedia of Genes and Genomes; TISCH2, Tumor Immune Single-cell Hub 2; TISIDB, Tumor-immune system interactions data types

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us