Table 2 Univariate and multivariate Cox regression analysis of TCIRG1 expression classifier and clinical characteristics with Overall Survival and Progression Free Interval in training cohort (n = 262)

Age

(≥ 60 vs. < 60)

1.836(1.155–2.918)

0.010

1.626(1.018–2.596)

0.042

1.317(0.831–2.087)

0.242

Gender

(Male vs. Female)

1.121(0.695–1.808)

0.639

1.891(1.088–3.288)

0.024

1.944(1.106–3.417)

0.021

TNM stage

(III-IV vs. I-II)

3.262(2.060–5.166)

< 0.001

2.248(1.365–3.701)

0.001

6.314(3.738–10.664)

< 0.001

5.197(2.977–9.072)

< 0.001

Pathological grade

(III-IV vs. I-II)

2.800(1.673–4.687)

< 0.001

1.766(1.016–3.701)

0.044

4.079(2.276–7.308)

< 0.001

2.340(1.284–4.267)

0.006

TCIRG1 expression

(High vs. Low)

2.409(1.554–3.736)

< 0.001

1.679(1.061–2.658)

0.027

2.085(1.319–3.297)

0.002

1.315(0.813–2.126)

0.265