Table 3 Univariate and multivariate Cox regression analysis of TCIRG1 expression classifier and clinical characteristics with Overall Survival and Progression Free Survival in validation cohort (n = 263)

Age

(≥ 60 vs. < 60)

1.729 (1.123–2.663)

0.013

1.398(0.898–2.178)

0.138

1.379(0.892–2.132)

0.149

Gender

(Male vs. Female)

0.817(0.537–1.242)

0.344

1.265(0.798–2.006)

0.317

TNM stage

(III-IV vs. I-II)

4.760(3.028–7.481)

< 0.001

3.509(2.159–5.701)

< 0.001

7.036(4.274–11.581)

< 0.001

5.868(3.476–9.907)

< 0.001

Pathological grade

(III-IV vs. I-II)

2.467(1.554–3.915)

< 0.001

1.432(0.878–2.335)

0.150

3.061(1.864–5.026)

< 0.001

1.994(1.171–3.394)

0.011

TCIRG1 expression

(High vs. Low)

2.373(1.566–3.596)

< 0.001

1.679(1.086–2.596)

0.020

1.658(1.075–2.559)

0.022

0.897(0.568–1.419)

0.643