Fig. 4
From: MiRNA-related metastasis in oral cancer: moving and shaking
Interaction between circIGHG and miR-142- 5p/IGF2BP3 in OSCC. CircIGHG is a circRNA derived from the IGHG locus. The expression of circIGHG is increased in OSCC cells and is positively correlated with poor prognosis in OSCC. MiR-142-5p can inhibit OSCC metastasis by targeting IGF2BP3, in return, circIGHG promotes EMT activation of OSCC cells by sponging miR-142-5p and upregulating IGF2BP3 [275]