Table 1 MiRNAs inhibiting the metastasis of oral cancer
From: MiRNA-related metastasis in oral cancer: moving and shaking
Type of oral cancer | miRNA (expression) | miRNA Target | Inhibition/ Induction of metastasis | Samples | Results | Ref |
|---|---|---|---|---|---|---|
OSCC | miR-23a-3p (Down) | Runx2 | Inhibition | Human (OSCC tissues), In vitro (TSCCA & CAL-27) | Upregulation of miR-23a-3p inhibits metastasis of OSCC by targeting Runx2 and inhibiting PI3K/Akt signaling pathway | [120] |
OSCC | miR-18a (Down) | HIF-1α | Inhibition | Human (OSCC tissues), In vitro (HSC-2 and YD-10B cell) | MiR-18a inhibits OSCC metastasis by targeting HIF-1α. | [121] |
TSCC | miR-320b (Down) | IGF2BP3 | Inhibition | Human (TSCC tissues), In vitro (SCC9 & CAL-27) | MiR-320b downregulation is related to lymphatic metastasis in TSCC patients. Upregulated miR-320b inhibits TSCC cell growth. | [122] |
OSCC | miR-186 & miR-655 (Down) | PTTG1 | Inhibition | In vitro (HSC2 & Ca9-22 cell) | MiR-186 and miR-655 regulate invasion by targeting PTTG1 & negatively regulating MMP-2 & MMP-9 activity. | [123] |
OSCC | miR-655 (Down) | Metadherin | Inhibition | Human (TSCC tissues), In vitro (SCC9 & CAL-27) | MiR-655 may suppress metastasis by inhibiting invasion and PTEN/AKT pathway. | [124] |
OSCC | miR‑198 (Down) | CDK4 | Inhibition | Human (OSCC tissues), In vitro (SCC-9 & Cal-27 cell) | Overexpression of miR‑198 inhibits invasion, EMT and metastasis of OSCC by targeting CDK4. | [125] |
OSCC | miR-489-3p | TWSIT | Inhibition | In vitro (SCC-4) | Ectopic miR-489-3p expression prevents OSCC invasion, migration, and metastasis by inhibiting TWSIT expression. | [126] |
OSCC | miR-5580-3p (Down) | LAMC2 | Inhibition | Human (OSCC tissues), In vitro (SCC-4 & Cal-27 cell) | MiR‑5580‑3p suppresses migration of OSCC by targeting LAMC2. | [127] |
OSCC | miR-29c | SERPINH1 | Inhibition | In vitro (SCC25 cells) | MiR-29c prevents migration, invasion, and metastasis of OSCC cells by targeting SERPINH1. | [128] |
OSCC | miR-132 | TGF-β1 | Inhibition | Human (OSCC tissues), In vitro (CAL-27/CDDP) | MiR-132 prevents OSCC invasion and increases chemosensitivity to cisplatin by inhibiting TGF-β1. | [129] |
OSCC | miR-504 (Down) | CDK-6 | Inhibition | Human (OSCC tissues), In vitro (Cal27 & Tca8113 cells) | Upregulated miR-504 prevents OSCC migration and invasion by targeting CDK-6 | [130] |
OSCC | miR-519d (Down) | MMP3 | Inhibition | Human (OSCC tissues), In vitro (HN30 & HN4 cells) | MiR-519d inhibits metastasis of OSCC cells by suppressing invasion and migration through targeting MMP-3. | [131] |
OSCC | miR-149-5p (Down) | TGFβ2 | Inhibition | Human (OSCC tissues), In vitro (CAL-27 & CAL-27/CDDP) | MiR-149-5p prevents OSCC cells from metastasizing by targeting TGFβ2. | [132] |
TSCC | miR-149 (Down) | Specificity protein 1 | Inhibition | Human (TSCC tissues), In vitro (CAL-27 & Tca8113 cells) | MiR-149 can prevent metastasis of TSCC cells by inhibiting invasion and migration by targeting specificity protein 1 | [133] |
OSCC | miR-365-3p (Down) | EHF | Inhibition | Human (OSCC tissues), In vitro (OC-3-IV-M), In vivo (CB17-SCID mice) | MiR-365-3p prevents OSCC cells from metastasizing by targeting EHF. | [134] |
OSCC | miR-107 (Down) | TRIAP1 | Inhibition | In vitro (OSC-4 and CAL-27 cells) | Upregulated miR-107 may suppress metastasis of OSCC cells by inhibiting migration through targeting TRIAP1. | [135] |
OSCC | miR-532-3p (Down) | CCR7 | Inhibition | Human (OSCC tissues), In vitro (CAL-27 & TCA8113 cells) | MiR-532-3p decreases invasion, migration, and OSCC EMT by targeting CCR7. | [81] |
TSCC | miR-940 | CXCR2 | Inhibition | In vitro (TSCCA & Tca8113 cells) | Overexpressed miR-940 may inhibit metastasis of TSCC cells by inhibiting invasion, migration and EMT process through targeting IL-8/CXCR2/NF-κB axis. | [82] |
TSCC | miR-320a (Down) | MRP2 | Inhibition | Human (TSCC tissues), In vitro (SCC4 cells) | MiR-320a can suppress metastasis of OSCC cells by inhibiting migration and invasion by targeting MRP2. | [136] |
OSCC | miR-300 (Down) | - | Inhibition | Human (OSCC tissues), In vitro (Cal-27 & Tca8113 cells) | MiR-300 inhibits metastasis of OSCC cells by suppressing EMT. | [137] |
OSCC | miR-34a-5p (Down) | AXL | Inhibition | In vitro (SCC1 & CAL27 cells), In vivo (BALB/c nude mice) | MiR-34a-5p can prevent OSCC cells from metastasizing by targeting AXL. | [65] |
TSCC | miR-34a | MMP9 & MMP14 | Inhibition | Human (TSCC tissues), In vitro (CAL27 cells) | MiR-34a suppresses metastasis of TSCC cells by inhibiting invasion and migration through targeting MMP9 and MMP14. | [66] |
OSCC | miR-34a (Down) | IL6R | Inhibition | Human (OSCC tissues), In vitro (Tca8113 cells) | Ectopic expression of miR-34a prevents metastasis of OSCC cells. | [67] |
OSCC | miR-1-3p (Down) | DKK1 | Inhibition | Human (OSCC tissues), In vitro (SCC-4 cells) | MiR-1-3p suppresses metastasis of OSCC cells by inhibiting migration through DKK1. | [138] |
OSCC | miR-218-5p | CD44 | Inhibition | In vitro (UM-SCC6) | MiR-218-5p may inhibit metastasis of OSCC cells by suppressing invasion through targeting CD44-ROCK pathway. | [139] |
OSCC | miR-375 (Down) | PDGF‑A | Inhibition | In vitro (UM1 & CAL‑27) | MiR-375 targets PDGF-A to prevent OSCC cells from metastasizing by reducing invasion and migration. | [140] |
OSCC | miR-376c-3p (Down) | HOXB7 | Inhibition | Human (OSCC tissues), In vitro (SCC-25 cells) | MiR-376c-3p inhibits metastasis of OSCC cells by reducing invasion and migration through targeting HOXB7. | [141] |
OSCC | miR-376c | - | Inhibition | Human (OSCC tissues), In vitro, In vivo | Upregulated miR-376c inhibits invasion, migration and metastasis of OSCC cells via regulating RUNX2-INHBA axis. | [142] |
OSCC | miR-377 (Down) | HDAC9 | Inhibition | Human (OSCC tissues), In vitro (UPCI-SCC-116cells) | MiR-377 can inhibit metastasis by suppressing migration through targeting HDAC9. | [143] |
OSCC | miR-143 (Down) | HK2 | Inhibition | Human (OSCC tissues), In vitro (Tca8113 cells & OECM-1) | MiR-143 can suppress metastasis of OSCC cells by inhibiting invasion and migration through targeting HK2. | [118] |
OSCC | miR-143 Down) | CD44 v3 | Inhibition | Human (OSCC tissues), In vitro (Tca-8113 & CAL-27 cells) | Upregulated miR-143 inhibits invasion and migration in Tca-8113 and CAL-27 cells. | [119] |
OSCC | miR-195-5p (Down) | TRIM14 | Inhibition | Human (OSCC tissues), In vitro (Cal27 & Tca83 cells) | MiR-195-5p prevents OSCC cells from migrating and invading by targeting TRIM14. | [144] |
Oral cancer | miR-30 family | mGluR5 | Inhibition | In vitro (SDF-1 stimulated B88 cells) | MiR-30 family may inhibit metastasis of oral cancer by targeting mGluR5. | [145] |
OSCC | miR-101 (Down) | CXCR7 | Inhibition | Human (OSCC tissues), In vitro (SCC-9, Fadu, Cal-27, & SCC-4 cells) | OSCC metastasis can be prevented by overexpression of miR-101 because it blocks migration and invasion via CXCR7. | [146] |
OSCC | miR-20a (Up) | - | Inhibition | Human (OSCC tissues), In vitro (Cal27 cells) | MiR-20a is elevated in HPV positive OSCCC samples. MiR-20a is overexpressed by HPV-16 E7, which prevents Cal27 cells from migrating and invading. | [147] |
OSCC | miR-204-5p (Down) | CXCR4 | Inhibition | Human (OSCC tissues), In vitro (Cal27 cells) | MiR-204-5p suppresses metastasis in OSCC cells. | [148] |
OSCC | miR-204 (Down) | SLUG and SOX4 | Inhibition | In vitro (SAS & OECM1 cells), In vivo (nude mice) | MiR-204 is decreased in tissues from lymph node metastases. MiR204 disrupts EMT properties of OSCC cells. | [149] |
OSCC | miR-23b & miR-27b (Down) | - | Inhibition | Human (OSCC tissues), In vitro (SAS & HSC3 cells) | Invasion and migration of OSCC cells are inhibited by upregulation of miR-23b or miR-27b. | [150] |
OSCC | miR-216a (Down) | EIF4B | Inhibition | Human (OSCC tissues), In vitro (SCC-4 & CAL 27 cells) | By targeting EIF4B, miR-216a prevents OSCC cells from metastasizing. | [151] |
OSCC | miR-338 (Down) | NRP1 | Inhibition | Human (OSCC tissues), In vitro (SCC-15 & Tca-8113 cells) | MiR-338 prevents OSCC cells from metastasizing by inhibiting NRP1. | [88] |
OSCC | miR-433 (Down) | HDAC6 | Inhibition | Human (OSCC tissues), In vitro (SAS & HSC2 cells), In vivo (BALB/c nude mice) | MiR-433 targets HDAC6. When miR-433 is expressed ectopically it prevents OSCC cells from migrating and invading. | [152] |
OSCC | miR-506 | GATA6 | Inhibition | Human (OSCC tissues), In vitro (SCC-4 & SCC-9 cells) | MiR-433 prevents OSCC cells from migrating and invading by targeting GATA6. | [153] |
OSCC | miR-320 (Down) | NRP1 | Inhibition | Human (OSCC tissues), In vitro (OC2 & HUVECs), In vivo (mice) | MiR-320 targets NRP1 to prevent OSCC cells from migrating. | [87] |
OSCC | miR-101 (Down) | AKT | Inhibition | Human (OSCC tissues), In vitro | Upregulated miR-101 decreases EMT and colony formation by suppressing AKT/mTOR. | [64] |
OSCC | miR-101 (Down) | TGF-βR1 | Inhibition | Human (OSCC tissues), In vitro (Tca8113 & SCC-9 cells) | OSCC metastasis is reduced by miR-101 by inhibiting TGF-βR1. | [154] |
OSCC | miR-101-3p (Down) | COL10A1 | Inhibition | Human (OSCC tissues), In vitro (TCA8113 cells) | Upregulated miR-101-3p may reduce OSCC metastasis by inhibiting migration and invasion. | [61] |
OSCC | miR-142 miR-128 (Down) | HOXA10 | Inhibition | Human (OSCC tissues), In vitro (SSC-25 & SCC-9 cells) | Upregulation of miR-128 and miR-142 suppressed metastasis of OSCC by targeting HOXA10. | [155] |
OSCC | miR-153-3p | Snail | Inhibition | Human (OSCC serum), In vitro (SCC4 cells) | MiR-153-3p suppressed activation of EMT via targeting Snail. | [88] |
OSCC | miR-495 (Down) | Notch1 | Inhibition | Human (OSCC tissues), In vitro (SCC-9, CAL-27, & Tca8113) | MiR-495 may inhibit metastasis by suppressing OSCC cell invasion by targeting Notch1. | [74] |
OSCC | miR-137 (Down) | BRD4 | Inhibition | Human (OSCC tissues), In vitro (Cal-27, SCC1 & SCC4) | Upregulated miR-137 promotes metastasis by increasing OSCC cell migration and invasion | [156] |
OSCC | miR-9 (Down) | CDK 4/6 | Inhibition | Human (OSCC tissues), In vitro (Tca8113) | Upregulated miR-9 induces apoptosis, cell cycle arrest and inhibits invasion of OSCC cells by targeting CDK 4/6 pathways. | [94] |
OSCC | miR-144/451a cluster (Down) | - | Inhibition | In vitro (UM-SCC083A & UPCI-SCC029B cells) | The miR-144/451a cluster prevents OSCC cells from migrating, invading, and metastasizing by lowering MIF and CAB39 levels. | [157] |
Oral cancer | miR-30a-5p (Down) | Fibroblast activation protein α (FAP) | Inhibition | Human (oral cancer patients), In vitro (SCC-15 & Tca-8113 cells) | MiR-30a-5p prevents OSCC cells from metastasizing by reducing invasion and migration through targeting FAP. | [158] |
TSCC | miR-29b (Down) | Sp1 | Inhibition | Human (TSCC tissues), In vitro (SCC-15 and CAL27) | MiR-29b reduces the invasion and migration of TSCC cells by targeting Sp1. | [159] |
TSCC | miR-200a | DEK | Inhibition | In vitro (SCC15 cells) | Ectopic miR-200a expression prevents TSCC from migrating and invading by targeting DEK. | [160] |
TSCC | miR-27b (Down) | ITGA5 | Inhibition | In vitro (SCC-9 & CAL 27 cells) | When MiR-27b is upregulated, it inhibits TSCC cell migration by targeting ITGA5, which stops the EMT process. | [161] |
TSCC | miR-200b or miR-15b (Down) | BMI1 | Inhibition | In vitro (SCC25-res & CAL27-res cells), In vivo (TSCC xenograft mice) | Upregulated miR-200b or miR-15b suppresses metastasis in chemo-resistant TSCC xenografts by targeting BMI1. | [162] |
TSCC | miR-944 | MMP10 | Inhibition | In vivo (mice), In vitro (AW13516 cell) | Upregulated miR-944 inhibits EMT, invasion, and migration of TSCC cells by targeting MMP10. | [68] |