Table 2 MiRNAs promoting metastasis in oral cancer
From: MiRNA-related metastasis in oral cancer: moving and shaking
Type of oral cancer | miRNA (Expression) | Target of miRNA | Inhibition/ Induction of metastasis | Samples | Results | Ref |
|---|---|---|---|---|---|---|
TSCC | miR-675-5p (Up) | - | Induction | In vitro (SCC9 cell) | MiR-675-5p ectopic expression caused TSCC to metastasize. | [212] |
TSCC | miR-17-5p | - | Induction | In vitro (CAL-27 cells) | MiR-17-5p may promote metastasis of TSCC cells via increasing migration. | [213] |
OSCC | miR-222 (Up) | CDKN1B | Induction | Human (OSCC tissues), In vitro (TCA-83, CAL-27, SOC-9 & CAL-27) | MiR-222 may promote OSCC metastasis, and invasion by targeting CDKN1B. | [203] |
OSCC | miR-155 (Up) | PTEN12 | Induction | Human (OSCC tissues), In vitro | PTEN12 is a target of overexpressed miR-155, which causes OSCC cells to metastasize. | [173] |
OSCC | miR-626 (Up) | RASSF4 | Induction | Human (OSCC tissues), In vitro (HSC2 & Ca9-22 cell) | MiR-626 expression was significantly correlated with lymph node metastasis. Uppregulated miR-626 promotes EMT, migration, and invasion of OSCC cells by targeting RASSF4. | [214] |
OSCC | miR-5100 (Up) | SCAI | Induction | In vitro (TCA-8113 cells) | MiR-5100 promotes invasion and migration of OSCC cells by targeting SCAI. | [215] |
OSCC | miR-142-5p | PTEN | Induction | Human (OSCC tissues), In vitro (HSC3-M3 & SAS cells) | Upregulated miR-142-5p increased OSCC invasion by targeting PTEN. | [169] |
OSCC | miR-211 (Up) | Bridging integrator-1 (BIN1) | Induction | Human (OSCC tissues), In vitro (HN6, HN4m SCC6, 9, & 25 cells) | MiR-211 may induce metastasis by promoting migration and invasion. | [216] |
OSCC | miR-133 | PDE1C | Induction | In vitro (SAS & OSC20) | MiR-133 promotes EMT phenotype. | [217] |
OSCC | miR-182-5p (Up) | MTSS1 | Induction | Human (OSCC tissues), In vitro (Tca8113 & Cal27 cells) | MiR-182-5p promotes invasion and migration of OSCC cells by targeting MTSS1. | [218] |
OSCC | miR-222-3p (Up) | CDKN1B | Induction | Human (OSCC tissues), In vitro (SCC-15 & Tca-83 cells) | MiR-222-3p promotes invasion and migration of SCC-15 and Tca-83 cells by targeting CDKN1B. | [202] |
OSCC | miR-146b (Up) | HBP1 | Induction | Human (OSCC tissues), In vitro (SCC25 & SCC9 cells) | MiR-146b promotes SCC25 and SCC9 cell invasion and migration by targeting HBP1. | [219] |
OSCC | miR-155-5p (Up) | ARID2 | Induction | Human (OSCC tissues), In vitro (Cal27 & HN4) | Patients with OSCC had a positive correlation between miR-155-5p levels and lymph node metastases. MiR-155-5p promotes OSCC cell invasion and migration by targeting ARID2. | [220] |
OSCC | miR-223-3p (Up) | SHOX2 | Induction | Human (OSCC tissues), In vitro (Tca-8113, SCC-9, Cal-27, & SCC-25 cells) | MiR-223-3p causes OSCC cells to metastasize by targeting SHOX2. | [221] |
OSCC | miR-223 (Up) | FBXW7 | Induction | Human (OSCC tissues), In vitro (SCC15 & OECM1 cells) | MiR-223-3p may induce metastasis of OSCC cells by increasing migration by decreasing FBXW7 expression. | [211] |
OSCC | miR-29b-1-5p (Up) | Cadherin-1 | Induction | Human (OSCC tissues), In vitro (KON cell) | MiR-29b-1-5p could enhance metastasis of OSCC cells by inducing EMT. | [174] |
OSCC | miR-29b | CX3CL1 | Induction | In vitro (TW2.6 MS-10 cells), In vivo (SCID mice injected with SAS/amiR-29b#4 cells) | MiR-29b induces migration of OSCC cells by decreasing CX3CL1 expression. | [222] |
OSCC | miR-134 | PDCD7 | Induction | Human (OSCC tissues), In vitro (SAS and OECM1 cells) | MiR-134 can induces metastasis by inhibiting migration and EMT by decreasing expression of PDCD7 and E-cadherin. | [175] |
OSCC | miR-200c-3p | - | Induction | In vitro (SQUU-B & SQUU-A cells) | MiR-200c-3p may contribute to metastasis by promoting invasion in the OSCC microenvironment. | [223] |
OSCC | miR-654-5p (Up) | Grb2-related adaptor protein (GRAP) | Induction | Human (OSCC tissues), In vitro (CAL-27/CDDP & Tca-8113/CDDP) | MiR-654-5p promotes metastasis of OSCC cells by increasing invasion and migration by regulating GRAP-mediated Ras/MAPK signaling. | [224] |
OSCC | miR-625-3p (Up) | SCAI | Induction | Human (OSCC tissues), In vitro (WSU-HN6 & SCC25 cells) | MiR-625-3p may encourage migration by targeting SCAI to cause OSCC cells to metastasize. | [225] |
OSCC | miR-196b (Up) | - | Induction | Human (OSCC tissues), In vitro (SAS & CAL-27 cells) | In SAS and CAL-27 cells, ectopic expression of miR-196b promotes EMT, migration, and invasion. | [226] |
Oral cancer | miR-196a and b | - | Induction | Human (oral cancer tissues), In vitro (OECM1 & SAS cells) | MiR-196a and miR-196b induce migration and invasion of OECM1 and SAS cells by regulating the NME4-JNK-TIMP1-MMP signaling pathway. | [227] |
OSCC | miR-448 (Up) | MPPED2 | Induction | Human (OSCC tissues), In vitro (CAL-27 cells) | Silencing miR-448 leds to inhibition of migration in Cal-27 cells. | [228] |
OSCC | miR-424-5p (Up) | SOCS2 | Induction | Human (OSCC tissues), In vitro (OEC-M1 and SCC-9 cells) | MiR-424-5p promotes OSCC cell migration and invasion by targeting SOCS2. | [229] |
OSCC | miR-187 (Up) | BARX2 | Induction | In vitro (SAS cells) | When MiR-187 was expressed ectopically, it promoted OSCC cell migration. | [230] |
OSCC | miR-155 | - | Induction | Human (OSCC tissues), In vitro (CAL27 cells ) | MiR-155 induces invasion and migration of OSCC cells by regulating BCL6/cyclin D2 axis. | [231] |
OSCC | miR-221 (Up) | MBD2 | Induction | In vitro (CAL-27 & UM1 cells), | MiR-221 expression was increased in metastatic cells compared to less metastatic OSCC cell lines. Downregulated miR-221 inhibits invasion and migration of metastatic cell lines (UM1 cells). | [232] |
Oral cancer | miR-518c-5p (Up) | - | Induction | In vitro (B88-SDF-1 cells & CAL27 cells), In vivo (BALB/c nude mice) | Upregulated miR-518c-5p promotes migration and metastasis of OSCC cells. | [233] |
TSCC | miR-21 (Up) | DKK2 | Induction | Human (TSCC tissues), In vitro (SCC25) | MiR-21 induces invasion of oral cancer cells by targeting DKK2. | [234] |
TSCC | miR-96 | MTSS1 | Induction | In vitro (Tca8113 cells), | MiR-96 promotes metastasis of Tca8113 cells by targeting MTSS1. | [193] |
TSCC | miR-424 & miR-19a (Up) | TGFBR3 | Induction | Human (TSCC tissues), In vitro (CAL-27 cells) | Upregulated miR-19a and − 424 induce EMT and migration of TSCC cells. | [83] |
TSCC | miR-373-3p (Up) | DKK1 | Induction | Human (TSCC tissues), In vitro (SCC-9 & UM1 cells) | MiR-373-3p induces metastasis and EMT by targeting the Wnt/β-catenin pathway. | [235] |
TSCC | miR-24 (Up) | FBXW7 | Induction | Human (TSCC tissues), In vitro (SCC15 & SCC25 cells) | MiR-24 can promote metastasis of TSCC cells by inducing migration and invasion by targeting FBXW7. | [210] |
TSCC | miR-24 | PTEN | Induction | Human (TSCC tissues), In vitro (CAL-27 cells) | MiR-24 induces invasion and migration of TSCC cells. | [172] |