Table 3 LncRNA/circRNA/miRNA networks in oral cancer metastasis
From: MiRNA-related metastasis in oral cancer: moving and shaking
Oral cancer type | circRNA/ lncRNA (expression) | miRNA (Expression) | Target of miRNA | Inhibition/ Induction of metastasis by miRNA | Results | Ref |
|---|---|---|---|---|---|---|
OSCC | circVAPA (Up) | miR-132 (Up) | HOXA7 | Inhibition | CircVAPA promoted OSCC growth by sponging miR-132, which likely suppressed the invasion, migration, and metastasis of oral cancer cells by targeting HOXA7. | [272] |
OSCC | LINC00662 (Up) | miR-144-3p (Down) | EZH2 | Inhibition | LINC00662 caused EMT, migration, and invasion of OSCC by sponging miR-144-3p. | |
OSCC | LINC00319 (Up) | miR-199a-5p (Down) | FZD4 | Inhibition | LINC00319 promoted OSCC metastasis by sponging miR-199a-5p. | [273] |
OSCC | ZEB1-AS1 (Up) | miR-23a (Down) | - | - | Lnc-ZEB1-AS1 induced OSCC metastasis by decreasing the expression of miR-23a. | [274] |
OSCC | circIGHG (Up) | miR-142-5p (Down) | IGF2BP3 | Inhibition | MiR-142-5p prevented OSCC metastasis possibly by targeting IGF2BP; conversely, circIGHG promoted EMT of OSCC cells by sponging miR-142-5p. | [275] |
TSCC | LTSCCAT (Up) | miR-103a-2-5p (Down) | SMYD3 | Inhibition | MiR-103a-2-5p prevented TSCC cells from metastasizing by targeting SMYD3, whereas lnc-LTSCCAT promoted TSCC metastasis. | [276] |
Oral cancer stem cell | Lnc-MEG3 (Up) | miR-421 (Down) | - | Inhibition | Lnc-MEG3 promoted the ability of oral cancer stem cells to invade, but co-transfection with miR-421 mimics suppressed the effect of lnc-MEG3. | [277] |
TSCC | Lnc-ADAMTS9-AS2 (Up) | miR-600 (Down) | EZH2 | Inhibition | Lnc-ADAMTS9-AS2 promoted TSCC migration and EMT by targeting miR-600. | [278] |
OSCC | circDHTKD1 (Up) | miR-326 (Down) | GAB1 | Inhibition | miR-326 may inhibit OSCC metastasis by downregulating GAB1 expression, conversely, circDHTKD1 induced metastasis of OSCC by sponging miR-326. | [279] |
OSCC | circ_0020377 | miR-194-5p | KLF7 | Inhibition | circ_0020377 promoted invasion and migration of OSCC cells by upregulating KLF7 expression levels through sponging of miR-194-5p. | [271] |
OSCC | lnc- SNHG5 (Up) | miR‑655‑3p (Down) | FZD4 | Inhibition | Lnc-SNHG5 promoted OSCC invasion and migration by sponging miR655-3p. MiR-655-3p targeted FZD4 and competed with lnc-SNHG5 to suppress the invasion and migration of SCC-4 cells. | [280] |
OSCC | lnc-RC3H2 (Up) | miR-101-3p | EZH2 | Inhibition | Lnc-RC3H2 promoted migration and invasion of OSCC cells by sponging miR-101-3p, . Upregulation of miR-101-3p targeted EZH2 to reduce RC3H2-induced invasion and migration in OSCC. | [281] |
OSCC | linc01234 (Up) | miR-433-3p | PAK4 | Inhibition | Linc01234 targeted miR-433-3p to promote OSCC metastasis | [282] |
OSCC | lnc-TIRY (Up) | miR-14 (Down) | - | Inhibition | Lnc-TIRY activated the Wnt/β-catenin pathway and promoted OSCC metastasis by sponging miR-14. | [283] |
OSCC | Lnc-GAS5 | miR-21 | PTEN | Induction | Lnc-GAS5 inhibited invasion, migration, and EMT of OSCC cells by targeting miR-21/PTEN axis. | [24] |
OSCC | circ_0000140 (Down) | miR-31 (Up) | LATS2 | Induction | Circ_0000140 blocked OSCC invasion and migration by sponging miR-31, which in turn blocked the Hippo signaling pathway. On the other hand, miR-31 encouraged OSCC cell invasion and migration by inhibiting LATS2. | [284] |
OSCC | circ_0000140 (Down) | miR-182-5p (Up) | CDC73 | Induction | Circ_0000140 inhibited metastasis of OSCC by increasing CDC73 through targeting miR-182-5p. | [23] |
OSCC | circ-PKD2 (Down) | miR-204‐3p (Up) | APC2 | Induction | Upregulation of miR-204‐3p promoted metastasis by increasing invasion and migration. CircPKD2 reduced OSCC migration and invasion by targeting miR204-3p | [22] |