Fig. 4

High ADAM8 expression identifies a group of HR+/HER2− breast cancer patients with poor survival. A 10-year Cox proportional hazards model for patients with the HR+/HER2− breast cancer subtype (n = 300 patients) was run using SAS 9.4 software to allow for age and race adjusted survival analysis, along with an adjusted survival curve based on ADAM8 expression levels from the ADP2 IHC assay. Survival was calculated as time from surgery until death or censored at time from surgery until last follow-up; if a patient survived beyond 10 years, they were censored at 10 years. Hazard Ratios with 95% confidence intervals (CI) and significance values of the parameter estimates using Wald’s Chi-Square test are presented. H-scores of 200 to 300, obtained through the ADP2 IHC assay, identified a group of patients at risk of poor outcome