Table 1 Summary of patient demographic and disease characteristics
Variable | Total | ADAM8 H-SCORE category | P-value | ||
|---|---|---|---|---|---|
Population | High | Low | Negative | ||
N = 490 | N = 115 | N = 51 | N = 324 | ||
H-score | 0.0 (0.0, 300.0) | 200.0 (200.0, 300.0) | 100.0 (50.0, 150.0) | 0.0 (0.0, 0.0) | < 0.0001 |
Age at diagnosis | 59.5 (28.5, 94.8) | 67.3 (31.0, 94.8) | 58.3 (34.5, 83.7) | 58.0 (28.5, 93.2) | < 0.0001 |
HER2 status | 0.1069 | ||||
Negative | 393 (80.2%) | 86 (74.8%) | 46 (90.2%) | 261 (80.6%) | |
Positive | 57 (11.6%) | 14 (12.2%) | 3 (5.9%) | 40 (12.3%) | |
Unknown | 40 (8.2%) | 15 (13.0%) | 2 (3.9%) | 23 (7.1%) | |
ER status | 0.7491 | ||||
Negative | 107 (22.0%) | 28 (24.3%) | 12 (23.5%) | 67 (20.9%) | |
Positive | 362 (74.3%) | 81 (70.4%) | 37 (72.5%) | 244 (76.0%) | |
Unknown | 18 (3.7%) | 6 (5.2%) | 2 (3.9%) | 10 (3.1%) | |
PR status | 0.2145 | ||||
Negative | 160 (32.7%) | 44 (38.3%) | 13 (25.5%) | 103 (31.9%) | |
Positive | 293 (59.9%) | 65 (56.5%) | 31 (60.8%) | 197 (61.0%) | |
Unknown | 36 (7.4%) | 6 (5.2%) | 7 (13.7%) | 23 (7.1%) | |
Race | 0.9142 | ||||
Asian | 2 (0.4%) | 2 (0.6%) | |||
Black/African American | 108 (22.0%) | 29 (25.2%) | 11 (21.6%) | 68 (21.0%) | |
Other | 1 (0.2%) | 1 (0.3%) | |||
Unknown | 2 (0.4%) | 1 (0.9%) | 1 (0.3%) | ||
White | 377 (76.9%) | 85 (73.9%) | 40 (78.4%) | 252 (77.8%) | |
Ethnicity | 0.0007 | ||||
Hispanic or Latino | 4 (0.8%) | 1 (0.9%) | 1 (2.0%) | 2 (0.6%) | |
Non-Hispanic | 364 (74.3%) | 100 (87.0%) | 42 (82.4%) | 222 (68.5%) | |
Unknown | 122 (24.9%) | 14 (12.2%) | 8 (15.7%) | 100 (30.9%) | |