CircRNAs in diagnosis, prognosis, and clinicopathological features of multiple myeloma; a systematic review and meta-analysis

Table 2 Main characteristics of the prognostic studies

Author’s name	Year	CircRNAs (n = 13)	MM^a patiens size	Sample type	Method	Survival indicator (OS^b)		HR Extraction	Follow up^*	NOS^e
Author’s name	Year	CircRNAs (n = 13)	MM^a patiens size	Sample type	Method	HR^c (95% CI^d)	P value	HR Extraction	Follow up^*	NOS^e
Fang Chen	2020	Circ-0069767	66	Bone marrow	qRT-PCR	0.22 (0.1–0.47)	0.0001	Indirectly	60	7
Hongyan Ma	2022	Circ-PSAP	50	Bone marrow	qRT-PCR	3.39 (0.99–3.88)	/	Indirectly	60	7
Haiyan Liu	2019	Circ-SMARCA5	105	Bone marrow	qRT-PCR	0.259 (0.119–0.565)	0.001	Directly	40	8
Lin Liu	2021	Circ-0001821	115	Bone marrow	qRT-PCR	2.342 (1.217–4.355)	0.031	Directly	60	8
Fang Chen	2020	Circ-CDYL	72	Bone marrow and PB^f	qRT-PCR	3.49 (1.59–7.60)	0.0017	Indirectly	60	7
Hui Zhou	2019	Circ-ITCH	92	Bone marrow	qRT-PCR	0.367 (0.156–0.865)	0.018	Directly	36	8
Xingxing Gong	2021	Circ- 0087776	136	PB (serum)	qRT-PCR	4.228 (2.564–6.974)	0.001	Directly	–	7
Shanshan Yu	2020	Circ‑ MYBL2	89	Bone marrow and serum	qRT-PCR	0.37 (0.18–0.74)	0.0052	Indirectly	50	6
Yanwei Luo	2020	Circ-MYC	122	PB (serum)	qRT-PCR	3.67 (1.65–5.58)	0.0001	Directly	60	8
Xiao Liu	2020	Circ-101,237	143	Bone marrow	qRT-PCR	4.22 (1.05–3.71)	0.035	Indirectly	60	7
Fan Zhou	2021	Circ-PTK2	60	Bone marrow	qRT-PCR	3.89 (1.54–9.79)	0.004	Indirectly	40	6
Fan Zhou	2021	Circ-AFF2	60	Bone marrow	qRT-PCR	0.29 (0.15–0.65)	0.003	Indirectly	40	6
Yan Li	2022	Circ-KCNQ5	43	Bone marrow	qRT-PCR	7.96 (2.65–23.80)	0.0001	Indirectly	60	8

^a Multiple myeloma; ^b Overall survival; ^c Hazard ratio; ^d 95% confidence interval; ^e Newcastle-Ottawa Scale; ^f Peripheral blood
^* Months

ISSN: 1475-2867