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Fig. 5 | Cancer Cell International

Fig. 5

From: Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma

Fig. 5

Flow cytometry analysis of the influences of PGRN on apoptosis in PTC cells by Annexin V-FITC-PI or Annexin V-APC/7AAD staining. (A) Knockdown of PGRN promoted the apoptosis of PTC cells (n = 6). (B) Overexpression of PGRN inhibited the apoptosis of PTC cells (n = 6). (C, D) Representative images and quantitation of the western blotting showed that the protein expression of BAD、BCL2、BAX and CyclinD1 in the PGRN knockdown/overexpression groups (n = 3). GAPDH was used as an internal control. Data are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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