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Fig. 6 | Cancer Cell International

Fig. 6

From: Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma

Fig. 6

PGRN promoted invasion and migration in ovarian cancer cells. (A) Knockdown of PGRN suppressed PTC cells invasion, overexpression of PGRN promoted PTC cells invasion (n = 9;×200). (B) Knockdown of PGRN inhibited PTC cells migration, overexpression of PGRN promoted PTC cells migration (n = 9;×200, Scale Bar = 100 μm). (C, D) Representative images and quantitation of the western blotting showed that the protein expression of E-Cadherin, N-Cadherin, vimentin and MMP2 in the PGRN knockdown/overexpression groups (n = 3). GAPDH was used as an internal control. Data are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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