Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma

Table 1 Relationship between PGRN and the clinical pathological features in papillary thyroid carcinoma

Clinical features	n	PGRN protein	P	PGRN mRNA	P
Gender Male Female	12 58	1.178 ± 0.199 0.949 ± 0.134	0.076	24.639 ± 11.984 23.659 ± 4.826	0.887
Age ≥ 55 < 55	16 54	0.992 ± 0.173 0.987 ± 0.143	0.419	28.380 ± 9.406 22.477 ± 5.084	0.227
Tumor size ≤ 2 > 2	45 25	0.887 ± 0.146 1.172 ± 0.192	0.228	23.114 ± 5.574 25.109 ± 4.222	0.089
Lymph node metastasis Yes No	50 20	1.127 ± 0.143 0.642 ± 0.174	0.021	28.925 ± 5.867 11.081 ± 4.222	0.014
Mutiplicity Yes No	32 38	0.936 ± 0.200 1.032 ± 0.135	0.197	26.552 ± 7.075 21.532 ± 5.692	0.568
Bilateral Yes No	16 54	1.053 ± 0.140 0.772 ± 0.189	0.259	24.735 ± 5.416 20.761 ± 6.922	0.685
Extra thyroid invasion Yes No			0.045		0.794
Extra thyroid invasion Yes No	4 66	1.839 ± 0.560 0.937 ± 0.117		18.764 ± 12.613 24.134 ± 4.672

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