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Fig. 6 | Cancer Cell International

Fig. 6

From: MALAT1/ mir-1-3p mediated BRF2 expression promotes HCC progression via inhibiting the LKB1/AMPK signaling pathway

Fig. 6

The carcinogenic effect of BRF2 may mainly depend on the inhibition of LKB1/AMPK signaling pathway. (a) The number of up-regulated genes and down-regulated genes in Huh7 cells by comparing the si-BRF2 group and the si-NC group. (b, c) Functional enrichment analysis including the GO and KEGG pathways was performed in the upregulated DEGs in Huh7-siBRF2. (d, e) Functional enrichment analysis including the GO and KEGG pathways was performed in the downregulated DEGs in Huh7-siBRF2. (f) The expression changes of AMPKα-2 mRNA levels after knockdown BRF2. (g) The expression changes of the LKB1-AMPK signaling pathway after knockdown of BRF2 by Western blotting. ** P < 0.01, *** P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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