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Fig. 8 | Cancer Cell International

Fig. 8

From: LncRNA CYP4A22-AS1 promotes the progression of lung adenocarcinoma through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes

Fig. 8

Effects of CYP4A22-AS1 on LUAD in vivo. A The nude mice tumors were removed for RT-qPCR. The expression of CYP4A22 was up-regulated in tumors of mice injected with CYP4A22-AS1-overexpressing cells. B As per the results of RT-qPCR, the expressions of EREG and BCL-2 were increased. C RT-qPCR was adopted to test the expression of markers of the EMT pathway in mice tumors. E-cadherin was decreased, while N-cadherin and Vimentin were increased in tumors of mice injected with CYP4A22-AS1-overexpressing cells. D IHC of p-AKT, p-ERK, p-MEK, BCL-2, and Vimentin in mice tumors, and their expression were all increased. E The underlying mechanism of CYP4A22-AS1 in LUAD. GAPDH was used as protein and mRNA control. All experiments were performed thrice. *p < 0.05 and **p < 0.01 demonstrated the statistical significance of the experimental data

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Cancer Cell International

ISSN: 1475-2867

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