Fig. 3
From: A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders
The tumor suppressive role of PTCSC3 in glioma cells. LncRNA PTCSC3 suppresses the activation of Wnt/β-catenin signaling pathway by targeting LRP6 and major players including active β-catenin, and Axin, as well as downstream targets of the pathway including c-myc, and cyclin D1. In addition, PTCSC3 inhibits EMT process in the glioma cells by blocking Snail, ZEB1, and fibronectin, while promoting E-cadherin