Fig. 11

ZBTB16 expression is up-regulated in OV and related to poor prognosis. A The representative immunohistochemistry (IHC) staining images of ZBTB16 expression of various specimens (including primary OV lesions, metastatic lesions, and normal controls) were listed. Original magnification × 200. B Compared with primary OC lesions and normal controls, metastatic lesions had higher ZBTB16 expression, measured through IRS score. C The IHC staining images of primary and metastatic tumor lesions from 5 representative OV patients. Original magnification × 200. D ZBTB16 expression was increased in patients who suffered recurrence or death, measured through IHC staining analysis of the tissue microarrays. E The Kaplan–Meier survival curves for the overall survival (OS, bottom) of 125 OV patients were shown, which reveal that the upregulation of ZBTB16 correlates with poor survival