Table 2 Overview of the seven potential differentially expressed coagulation-related genes (DE-CRGs) with prognosis value of ovarian cancer (OV) [16,17,18,19,20,21,22,23]
Gene | Gene name | Function in OV | Refs. |
|---|---|---|---|
SERPINA10 | Serpin Family A Member 10 | SERPINA10, a member of the serpin superfamily of proteinase inhibitors related to extracellular matrix (ECM), could be a biomarker for predicting drug sensitivity and survival in platinum-based chemotherapy of OV, though the underlying mechanism is still unknown | [16] |
CD38 | CD38 Molecule | CD38 could predict favorable prognosis in OV, by enhancing immune infiltration and anti-tumor immunity in tumor microenvironment | [17] |
ZBTB16 | Zinc Finger And BTB Domain Containing 16 | Unknow in OV. ZBTB16 could bind to specific DNA sequences with the C-terminal zinc fingers, so as to suppress transcription via recruiting co-repressors with the amino terminal POZ domain. ZBTB16 affects diverse signaling pathways including cell cycle, differentiation, and programmed cell death pathways in solid tumors | |
ALG9 | ALG9 Alpha-1,3-Glucosyltransferase | Unknow in OV. In acute myeloid leukemia, the mannosyl-transferase ALG9 regulates the proliferation and drug resistance in tumor cells, which could be reversed by the sponge effect of MEG3/miR-155 | [20] |
ANO6 | Anoctamin 6 | Unknow in OV. In glioma, ANO6 could promote tumor cell proliferation and invasion, by regulating the ERK signaling pathway | [21] |
CFI | Complement Factor I | Unknow in OV. Complement factor I, as one of the key negative regulators of the complement system, could upregulate the expression of matrix metalloproteinase-2/-13 and promote tumor invasion in cutaneous squamous carcinoma cells | [22] |
RUNX1 | RUNX Family Transcription Factor 1 | RUNX1, as a subunit of core-binding factors in hematopoiesis and leukemia, could regulate cisplatin-induced apoptosis in OV | [23] |