Table 1 Phytochemical and other substances with off target effects on telomerase

Epigallocatechin gallate

Camellia sinensis

1,2

BC, ML

[86]

Papaverine

Papaveraceae

1,2

BC

[265]

Quercetin

Tea, onion,wine, flavonoids fruits, vegetables

2,5

CA

[266]

Genistein

Secondary plant metabolites and soybean

1,2

BC

[146]

Genistein

Secondary plant metabolites and soybean

4

BC, CC, LC, OC

[267]

Curcumin

Curcuma longa

1,2

BC, leukemia

[141]

Ginsenoside Rk1

Sun Ginseng

1,2,5

LC

[268]

Allicin and ajoene

Garlic

2,5

GC

[138]

Resveratrol

Hellebores, grapes, peanuts, legumes, red wine

1,2

[266]

Silibinin

Silybum marianum

1,2

PC

[269]

Epigallocatechin gallate

Camellia sinensis

3

BT

[270]

Wortmanin

-Pinicillium funiculosum,

-Talaronyces wortmannii

2

Leukemia

[271]

Rapamycin

Streptomyces hygroscopicus

1,2

Glioma, CC

[271, 272]

Trichostatin A

Streptomyces platensis

2

BT (Pediatric)

[271, 272]

1,25-dihydroxyvitamin D3

Endogenous (skin) UV exposure

1,2

OC

[273]

All-trans retinoic acid

Vitamin A derivatives

1,2

BC

[274]

Vitamin E

Plant oils

2

OC

[275]

5-Azacytidine

Synthetic chemical (analog of cytidine)

1

LC, MDS

[276]

Suramin

Synthetic chemical (chemosensitizer)

1

HECC

156]

Rapamycin (Sirolimus)

Streptomyces hygroscopicus

1,2

CC

[272]

Aspirin

NSAID

1,2

CC

[157]

Indomethacin

NSAID

1,2

CC

[157

Tamoxifen

Nonsteroidal antiestrogen

1

LC,BC, EMC

[277]

Melatonin

Tryptophan metabolite (hormone)

1,2

BC

[165]

Cisplatin

Chemotherapeutic drug

1,2

TC, OC, Mult

[164]

Doxorubicin

Cytotoxic anthracycline antibiotic

2

BC, Panc.C, Mult

[278]