Fig. 3

The signal pathway mediated by CD93 in ECs. (1) Integrin participated in the activation of Src and FAK, and CD93 ensured FAK activation. (2) Cell adhesion on laminin caused DG phosphorylation, phosphorylated DG recruits Src, integrin-induced Scr activation, and activated Src was induced to phosphorylate the CD93 cytoplasmic domain. Phosphorylated CD93 recruits and phosphorylated Cb1, phosphorylated the Cb1 receptor, and interacted with Crk, which interacted with DOCK180 and regulated downstream Rho GTPases, including Rac1, Cdc42, and RhoA. (3) The cytoplasmic region of CD93 interacted with moesin and F-actin. (4) Dystroglycan interacted with dystrophin, and dystrophin interacted with F-actin. (5) The small GTPase Rab5c participated in cycling CD93 to the surface of ECs, and CD93, MMRN2, and β1 integrin form a complex in the Rab5c endosomal compartment

Alt Text: There are two connected cells in the figure, the left side depicts the intrinsic signaling pathway, and the right side depicts the changes in the related protein backbone and the transport of molecules