Fig. 6

DSCC1 interacts with HSP90AB1 and promotes the progression of LUAD. (A) LUAD cells were collected, and immunoprecipitations with DSCC1 antibody or IgG were performed. DSCC1 interacting proteins were identified by immunoprecipitation coupled to mass spectrometry. (B-C) DSCC1 coexpressed genes were identified by UALCAN platform, and A Venn diagram was generated by overlapping DSCC1 coexpressed genes and DSCC1 interacting proteins. (D) Immunoprecipitation was performed to verify the interaction between DSCC1 and HSP90AB1. (E) The data was obtained from LinkedOmics. (F-G) LUAD cells with high level of DSCC1 were transfected with control siRNA and HSP90AB1 siRNA for 24 h, and migrative abilities of LUAD cells were determined by wound healing assay. (H-I) LUAD cells with high level of DSCC1 were transfected with control siRNA and HSP90AB1 siRNA for 48 h, and the expression of the indicated proteins were detected by western blot