Fig. 7

DSCC1 promotes LUAD progression via regulating ER stress and HSP90AB1. (A) The data was obtained from LinkedOmics. (B) LUAD cells were treated with control siRNA and DSCC1 siRNA for 48 h, and the expression of the indicated proteins were detected by western blot. (C) LUAD cells were treated with DSCC1 overexpressing plasmid and empty vector for 48 h, and the expression of the indicated proteins were detected by western blot. (D-E) LUAD cells were transfected with DSCC1 plasmid and empty vector for 48 h, then treated with thapsigargin (100 nM for NCI-H1299, and 10 nM for A549) for 24 h, and the migrative ability of LUAD cells were detected. (F) LUAD cells overexpressing DSCC1 were transfected with control siRNA and HSP90AB1 siRNA for 48 h, and the expression of the indicated proteins were detected by western blot