Fig. 8From: Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and cell proliferation in gliomaSchematic of MYH9 promoting glioma development. MYH9 bound to NAP1L1, and further inhibited ubiquitination and degradation of NAP1L1 by recruiting USP14. The upregulated NAP1L1 increased the binding with c-Myc and further activated c-Myc, which Induce CCND1/CDK4 expression, and thus promotes the cell proliferation and temozolomide resistanceBack to article page