Fig. 3

Active ARF6 accelerates tumor growth in HCC in vivo. (A) Subcutaneous tumors from Huh7 cells injected into the flank of nude mice. (B) Volume of subcutaneous tumors from the two groups were measured at indicated days after injection (n = 5). (C) Tumor volume and weight were compared between the two groups after the mice sacrificed. (D) The expression of ARF6, P21, Ki67 and p-STAT3 in indicated subcutaneous xenografts confirmed with HE staining was determined by IHC (scale bar: 200 μm). (E) expression scoring of above these factors was conducted. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001