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Fig. 2 | Cancer Cell International

Fig. 2

From: The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo

Fig. 2

UA derivative 5 elevates cytosolic Ca2+ levels in breast cancer cells. A Relative level of Ca2+ in MCF-7 cells treated with vehicle (DMSO, 100%) or 5 at the indicated concentrations for 6 h. B-C Effect of 2-APB (30 µM, B) or 2- BAPTA (10 µM, C) 1-h pretreatment on Ca2+ levels in MCF-7 cells treated or not with compound 5. D-E: Effect of 2-APB (D) or BAPTA (E) pretreatment on the viability of MCF-7 cells treated or not with 5 for 24 h. The data are shown as the mean ± SE (n = 7–11). Statistical significance was determined by ANOVA followed by Dunnett’s (A) or Sidak’s (B-E) post hoc tests: a—P < 0.0001, b—P < 0.001, c—P < 0.05, n.s.—not significant

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Cancer Cell International

ISSN: 1475-2867

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