Fig. 2
From: Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
Immunogenic cell death (ICD) inducer causes regulated kind of cell death through ROS production and endoplasmic reticulum (ER) stress in tumor cells. Dead tumor cells expose or release damage associated molecular patterns (DAMPs) such as adenosine Triphosphate (ATP), calreticulin (CRT), High mobility group box protein 1(HMGB1) and Heat shock proteins (HSPs). DAMPs cause functional maturation of dendritic cells through binding to their specific receptors. Mature DCs present cancer specific antigens to T cells and activate anticancer immune response against remained cancer cells