Fig. 3
From: Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
Natural compounds induce ICD through different mechanism leading to apoptotic type of cell death. Induction of oxidative stress in mitochondria and endoplasmic reticulum (RT) is the most common phenomena in ICD induced by natural agents. Releasing cytochrome C, activation of PERK/eIF2α/ATF4/CHOP pathway, prevention of NF-κB, increasing TNFα expression and inhibiting STAT3 activation have been reported as the involving signaling pathways in ICD by natural agents