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Fig. 7 | Cancer Cell International

Fig. 7

From: Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin

Fig. 7

Schematic representation of targeting USP5 by WP1130 and Vialinin A for suppressing Wnt/β-catenin signaling, cancer stemness, and metastasis in lung cancer. The interaction between USP5 and β-catenin leads to the deubiquitylation of β-catenin and inhibition of proteasome-mediated degradation of β-catenin. Stabilized β-catenin then enters nucleus, activates the transcription of target genes, promotes cancer cell stemness, invasion, metastasis and tumor initiation

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Cancer Cell International

ISSN: 1475-2867

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