Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

Table 3 Correlation between the clinicopathological features and Disease-Free survival in HNSCC

Variable	Category	Univariate analysis			Multivariate analysis
Variable	Category	HR	95% CI	p	Adjusted HR	95% CI	p
Age	≦51 vs > 51	0.932	0.59–1.43	0.724	0.742	0.46–1.21	0.228
Gender	Female vs male	0.814	0.30–2.23	0.689	0.871	0.28–2.69	0.810
Tumor site	Oral	Reference			Reference
	Oropharynx	0.609	0.30–1.23	0.168	0.715	0.33–1.53	0.387
	Hypopharynx/larynx	0.931	0.53–1.65	0.806	0.477	0.28–0.98	0.046
ECOG PS	0	Reference			Reference
	1	4.129	2.23–7.63	< 0.001	3.07	1.50–6.26	0.002
	2	18.296	8.88–37.70	< 0.001	9.478	3.90–23.06	0.001
T stage	1–3 vs 4A–B	0.478	0.25–0.71	0.001
N stage	Negative vs positive	0.515	0.32–0.83	0.005
AJCC stage	I–III vs IVA–B	0.404	0.25–0.67	< 0.001	0.917	0.51–1.64	0.770
LVI	Negative vs positive	0.521	0.33–0.82	0.005	0.703	0.42–1.17	0.177
PNI	Negative vs positive	0.326	0.21–0.52	< 0.001	0.507	0.29–0.88	0.017
ENE	Negative vs Positive	0.221	0.14–0.35	< 0.001	0.298	0.15–0.58	0.001
P16 expression	Negative vs positive	1.725	0.83–3.59	0.145	1.385	0.61–3.16	0.438
Alcohol drinking	No vs yes	1.050	0.65–1.70	0.844	0.890	0.52–1.54	0.676
Smoking	No vs yes	0.742	0.42–1.32	0.313	1.222	0.67–2.45	0.519
Betel nuts	No vs yes	0.426	0.25–0.72	0.002	0.555	0.32–0.98	0.041
DM	No vs yes	1.005	0.63–1.40	0.983	1.228	0.73–2.07	0.439
Hypertension	No vs yes	1.047	0.67–1.63	0.841	1.227	0.74–2.03	0.425
Viral hepatitis	No vs yes	0.838	0.53–1.34	0.458	1.310	0.74–2.33	0.358
MDK	Weak vs strong	0.446	0.29–0.70	0.001	0.312	0.15–0.66	0.038
AT1R	Weak vs strong	0.552	0.35–0.86	0.009	0.755	0.44–1.29	0.303

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