Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

Table 4 Overall survival associated with clinicopathological factors in post-operation HNSCC patients

Variable	Category	Univariate analysis			Multivariate analysis
Variable	Category	HR	95% CI	p	Adjusted HR	95% CI	p
Age	≦51 vs > 51	1.008	0.66–1.54	0.970	0.683	0.43–1.10	0.113
Gender	Female vs male	0.305	0.08–1.24	0.097	0.510	0.12–2.25	0.373
Tumor site	Oral	Reference			Reference
	Oropharynx	1.023	0.59–1.78	0.935	0.648	0.31–1.36	0.253
	Hypopharynx/larynx	0.610	0.28–1.35	0.221	0.477	0.24–0.95	0.034
ECOG PS	0	Reference			Reference
	1	4.355	2.42–7.83	< 0.001	2.81	1.42–5.60	0.003
	2	17.229	8.73–34.00	< 0.001	7.662	3.16–18.58	< 0.001
T stage	0–3 vs 4A–B	0.594	0.39–0.91	0.016
N stage	Negative vs positive	0.507	0.32–0.80	0.003
AJCC stage	I–III vs IVA–B	0.411	0.26–0.66	< 0.001	1.035	0.59–1.83	0.905
LVI	Negative vs positive	0.469	0.31–0.72	0.001	0.449	0.28–0.72	0.001
PNI	Negative vs positive	0.279	0.18–0.44	< 0.001	0.608	0.35–1.06	0.077
ENE	Negative vs positive	0.179	0.11–0.0.28	< 0.001	0.241	0.13–0.46	< 0.001
P16 expression	Negaive vs positive	2.814	1.23–6.46	0.015	2.452	0.98–6.13	0.055
Alcohol drinking	No vs yes	1.031	0.65–1.64	0.896	0.850	0.51–1.42	0.535
Smoking	No vs yes	0.494	0.26–0.93	0.029	0.862	0.44–1.68	0.519
Betel nuts	No vs yes	0.506	0.31–0.82	0.006	0.701	0.41–1.19	0.188
DM	No vs yes	0.754	0.49–1.16	0.196	1.093	0.68–1.75	0.712
Hypertension	No vs yes	0.794	0.52–1.22	0.289	0.736	0.45–1.20	0.216
Viral hepatitis	No vs yes	0.590	0.38–0.91	0.017	0.711	0.40–1.26	0.240
MDK	Weak vs strong	0.433	0.28–0.66	< 0.001	0.475	0.28–0.82	0.007
AT1R	Weak vs strong	0.472	0.31–0.72	0.001	0.597	0.35–1.03	0.065

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