Table 1 Information of cullin in gastrointestinal tumors
From: Role of non-canonical post-translational modifications in gastrointestinal tumors
CUL | Neddylation status | Cancer type | Regulatory proteins(axis) | Effects | References |
|---|---|---|---|---|---|
CUL1 | Neddylation | Gastric cancer | P21, P27,CDT1 | Inhibition of CUL1 suppress tumor cell proliferation and promote tumor cell apoptosis | |
CUL1 | de-neddylation | SI-NETs | CSN5, DKK1, TAZ | De-neddylation of CUL1 affects tumor progression | [75] |
CUL3 | Neddylation | Gastric cancer | KEAP1-CUL3-Nrf2 | Promoting CUL3 can inhibit cell growth and induce cell apoptosis | [78] |
CUL4A | Neddylation | Gastric cancer | NF-KB | Inhibition of CUL4A can inhibit tumor migration | |
CUL5 | Neddylation | Gastric cancer | NOXA | Promoting CUL5 can inhibit cell growth and promote apoptosis | [81] |
CUL5 | Neddylation | Colorectal cancer | NOXA | Promoting CUL5 promotes tumor growth and leads to drug resistance | [74] |