Table 2 Information of PADs in gastrointestinal tumors
From: Role of non-canonical post-translational modifications in gastrointestinal tumors
Isozyme | Cancer | Citrullinated protein | Effects | References |
|---|---|---|---|---|
PAD2 | Colorectal cancer | β-catenin | PAD2 can block Wnt signaling pathway, block cell cycle and inhibit the proliferation of cancer cells | |
PAD4 | Gastric cancer | CXCR2, KRT14,TNF-α, IL-8, Histone chip H3R26Cit and histone of NETs | PAD4 promotes the formation and metastasis of gastric cancer and affects tumor progression | |
PAD4 | Colorectal cancer | ING4, GSK3β, ECM | PAD4 promotes tumor proliferation and migration, facilitates the growth of colorectal cancer cells metastasized to the liver |