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Fig. 1 | Cancer Cell International

Fig. 1

From: Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis

Fig. 1

Hypoxia and RP11-367G18.1 variant 2 co-upregulated genes involve in tumor progression. (A) RNA-seq revealed that genes were differentially expressed following hypoxia (up) and RP11-367G18.1 variant 2 overexpression (bottom) in MCF7 cells. (B) Bar charts show the GO analysis results of upregulated genes under hypoxia (up) and RP11-367G18.1 variant 2 overexpression (bottom). (C) Venn graph showed the number of hypoxia- and RP11-367G18.1 variant 2-upregulated genes in MCF7 cells. (D) Heatmap analysis of hypoxia and RP11-367G18.1 variant 2 co-upregulated genes (n = 306). (E) GSEA revealed that hypoxia and RP11-367G18.1 variant 2 co-upregulated genes were enriched in the hypoxia, EMT, angiogenesis, and inflammatory response pathways. For hypoxic conditions, cells were cultured in 1% O2, 5% CO2, and 94% N2 for 18 h. FC, fold-change; N, normoxia; H, hypoxia; V2, variant 2

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Cancer Cell International

ISSN: 1475-2867

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