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Fig. 6 | Cancer Cell International

Fig. 6

From: Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis

Fig. 6

RP11-367G18.1 variant 2–YY1 complex is essential for hypoxia-induced tumorigenicity. (A) Knockdown of YY1 decreased the colony formation of FADU cells overexpressing RP11-367G18.1 variant 2. (B) Knockdown of RP11-367G18.1 variant 2 suppressed the colony formation of FADU cells overexpressing YY1. (C) Knockdown of RP11-367G18.1 variant 2 or YY1 suppressed the colony formation of H1299 cells overexpressing HIF-1α (ΔODD). (D) Knockdown of RP11-367G18.1 variant 2 or YY1 suppressed HIF-1α (ΔODD)-enhanced tumor volume of FADU cell-derived xenografts. Scr, Scrambled; Cont, control; V2, variant 2. Data are represented as the mean ± SD. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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