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Fig. 8 | Cancer Cell International

Fig. 8

From: Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis

Fig. 8

Schematic representation of the mechanism by which the RP11-367G18.1 variant 2–YY1 complex regulates hypoxia-inducible gene expression. In a hypoxic tumor microenvironment, RP11-367G18.1 variant 2 and YY1 are regulated by HIF-1α. RP11-367G18.1 variant 2 and YY1 form a complex and activate H4K16Ac to increase the expression levels of hypoxia-inducible genes, TGFBI, VEGFC, HK2, and LIF

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Cancer Cell International

ISSN: 1475-2867

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