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Table 2 Clinical characteristics of patients after PSM

From: Prediction model for hyperprogressive disease in patients with advanced solid tumors received immune-checkpoint inhibitors: a pan-cancer study

Characteristics

Non-HPD

HPD

p value

Method

N

216

36

  

Gender, N (%)

  

0.253

Chisq test

 Female

58 (23.0%)

13 (5.2%)

  

 Male

158 (62.7%)

23 (9.1%)

  

Pathology type, N (%)

  

0.112

Yates' correction

 Adenocarcinoma

106 (42.1%)

22 (8.7%)

  

 Squamous

55 (21.8%)

12 (4.8%)

  

 Small Cell Carcinoma

29 (11.5%)

2 (0.8%)

  

 Sarcoma

2 (0.8%)

0 (0%)

  

 Others

24 (9.5%)

0 (0%)

  

Differentiation, N (%)

  

0.150

Yates' correction

 Low Differentiation

128 (50.8%)

18 (7.1%)

  

 Low To Median Differentiation

30 (11.9%)

3 (1.2%)

  

 Median Differentiation

34 (13.5%)

12 (4.8%)

  

 Median To High Differentiation

1 (0.4%)

0 (0)

  

 Unknown

23 (9.1%)

3 (1.2%)

  

No gene mutation, N (%)

  

0.504

Chisq test

 No

49 (19.4%)

10 (4.0%)

  

 Yes

167 (66.3%)

26 (10.3%)

  

Ki67, N (%)

  

0.711

Yates' correction

 0–25%

17 (6.7%)

3 (1.2%)

  

 26–50%

20 (7.9%)

5 (2%)

  

 51–75%

18 (7.1%)

1 (0.4%)

  

 76–100%

19 (7.5%)

4 (1.6%)

  

 Unknown

142 (56.3%)

23 (9.1%)

  

TNM, N (%)

  

0.705

Yates' correction

 III

20 (6.7%)

3 (1.2%)

  

 IV

194 (77.0%)

32 (12.7%)

  

 Unknown

2 (0.8%)

1 (0.4%)

  

Smoking, N (%)

  

0.452

Yates' correction

 Never

103 (40.9%)

20 (7.9%)

  

 Ever

76 (30.2%)

13 (5.2%)

  

 Current

33 (13.1%)

2 (0.8%)

  

 Unknown

4 (1.6%)

1 (0.4%)

  

Drinking, N (%)

  

0.218

Yates' correction

 Never

120 (47.6%)

22 (8.7%)

  

 Ever

37 (14.7%)

9 (3.6%)

  

 Current

56 (22.2%)

4 (1.6%)

  

 Unknown

3 (1.2%)

1 (0.4%)

  

Family History of Tumor, N (%)

  

0.028

Yates' correction

 Yes

61 (24.2%)

8 (3.2%)

  

 No

150 (59.5%)

24 (9.5%)

  

 Unknown

5 (2.0%)

4 (1.6%)

  

KPS score, N (%)

  

0.948

Yates' correction

 10–20 point

7 (2.8%)

1 (0.4%)

  

 30–40 point

2 (0.8%)

0 (0)

  

 70–80 point

46 (18.3%)

9 (3.6%)

  

 90–100 point

160 (63.5%)

26 (10.3%)

  

 Unknown

1 (0.4%)

0 (0)

  

Combined Chemotherapy, N (%)

  

0.181

Chisq test

 Yes

110 (43.7%)

14 (5.6%)

  

 No

106 (42.1%)

22 (8.7%)

  

Combined Antiangiotherapeutics, N (%)

  

0.038

Chisq test

 No

157 (62.3%)

32 (12.7%)

  

 Yes

59 (23.4%)

4 (1.6%)

  

Combined Target Therapy,N (%)

  

1.000

Yates' correction

 No

210 (83.3%)

35 (13.9%)

  

 Yes

6 (2.4%)

1 (0.4%)

  

Combined Radiotherapy, N (%)

  

0.745

Yates' correction

 No

197 (78.2%)

34 (13.5%)

  

 Yes

19 (7.5%)

2 (0.8%)

  

Combined Other Therapy, N (%)

  

0.209

Chisq test

 No

84 (33.3%)

18 (7.1%)

  

 Yes

132 (52.4%)

18 (7.1%)

  

Lung Metastasis, N (%)

  

0.440

Chisq test

 No

105 (41.7%)

20 (7.9%)

  

 Yes

111 (44.0%)

16 (6.3%)

  

Brain Metastasis, N (%)

  

0.245

Chisq test

 No

182 (72.2%)

33 (13.1%)

  

 Yes

34 (13.5%)

3 (1.2%)

  

Bone Metastasis, N (%)

  

0.335

Chisq test

 No

151 (59.9%)

28 (11.1%)

  

 Yes

65 (25.8%)

8 (3.2%)

  

Adrenal Metastasis, N (%)

  

0.040

Yates' correction

 No

187 (74.2%)

36 (14.3%)

  

 Yes

29 (11.5%)

0 (0)

  

Subcutaneous Metastasis, N (%)

  

1.000

Yates' correction

 No

213 (84.5%)

36 (14.3%)

  

 Yes

3 (1.2%)

0 (0)

  

Muscle Metastasis, N (%)

  

0.598

Fisher test

 No

210 (83.3%)

36 (14.3%)

  

 Yes

6 (2.4%)

0 (0)

  

Meningeal Metastasis, N (%)

  

1.000

Fisher test

 No

215 (85.3%)

36 (14.3%)

  

 Yes

1 (0.4%)

0 (0)

  

Pericardial Metastasis, N (%)

  

0.598

Fisher test

 No

210 (83.3%)

36 (14.3%)

  

 Yes

6 (2.4%)

0 (0)

  

Intraabdominal Metastasis, N (%)

  

0.849

Chisq test

 No

171 (67.9%)

29 (11.5%)

  

 Yes

45 (17.9%)

7 (2.8%)

  

Pancreatic Metastasis, N (%)

  

0.782

Yates' correction

 No

211 (83.7%)

36 (14.3%)

  

 Yes

5 (2.0%)

0 (0)

  

Liver Metastasis, N (%)

  

0.169

Chisq test

 No

143 (56.7%)

28 (11.1%)

  

 Yes

73 (29.0%)

8 (3.2%)

  

Non-draining Areas Metastasis, N (%)

  

0.323

Yates' correction

 No

209 (82.9%)

33 (13.1%)

  

 Yes

7 (2.8%)

3 (1.2%)

  

Pleural Metastasis, N (%)

  

0.366

Yates' correction

 No

197 (78.2%)

35 (13.9%)

  

 Yes

19 (7.5%)

1 (0.4%)

  

 Age, Median (IQR)

58 (51, 67)

58 (50.25, 66.25)

0.773

Wilcoxon

 Height, Mean ± Sd

1.685 ± 0.074

1.668 ± 0.079

0.225

T test

 Weight, Median (IQR)

63 (56, 71)

61 (51.75, 70)

0.309

Wilcoxon

 BMI, Median (IQR)

22.519 (19.794, 24.612)

21.967 (18.423, 25.025)

0.755

Wilcoxon

  1. KPS Karnofsky performance status, BMI body mass index, IQR interquartile range